Conference Presentations

The Florey Neuroscience Seminar Series (October 2025) – Final PhD Oration & Public Seminar.
Focal Cortical Malformations in Epilepsy: Disease Modelling, Mechanisms, and Precision Medicine.
*Variants and earlier versions of this presentation were given as talks and seminars at the Neuroscience Center and Helsinki Institute of Life Science (HiLIFE) at the University of Helsinki, the A.I. Virtanen Institute for Molecular Sciences at the University of Eastern Finland in Kuopio, the Kavli Institute for Systems Neuroscience at the Norwegian University of Science and Technology (NTNU) in Trondheim, the Amsterdam University Medical Center (UMC), and at The Florey Epilepsy and Neurodevelopment Seminar Series.

Epilepsy Melbourne Meeting 2026 – Poster Presentation.
The HCN channel inhibitor Org 34167 reduces epileptiform activity in an in utero electroporation-based mouse model of TSC/FCD2B.

Federation of European Neuroscience Societies (FENS) Regional Meeting 2025, and the Norwegian Research School in Neuroscience (NRSN) Pre-Meeting (Oslo, Norway) – Oral and Poster Presentations.
James Spyrou, Lauren E Bleakley, Hannah Vanyai, Snezana Maljevic, Paul J Lockhart, Katherine B Howell, Christopher A Reid.
The HCN channel inhibitor Org 34167 reduces epileptiform activity in an in utero electroporation-based mouse model of TSC/FCD2B.
*Awarded a travel stipend supported by FENS, NRSN and NORA for the abstract.

Epilepsy Melbourne Meeting 2025 – Oral and Poster Presentation.
James Spyrou, Lauren E Bleakley, Hannah Vanyai, Snezana Maljevic, Paul J Lockhart, Katherine B Howell, Christopher A Reid.
The HCN channel inhibitor Org 34167 reduces epileptiform activity in an in utero electroporation-based mouse model of TSC/FCD2B.

Epilepsy Melbourne Meeting 2024 – Oral and Poster Presentation.
James Spyrou, Khaing Phyu Aung, Hannah Vanyai, Richard J Leventer, Snezana Maljevic, Paul J Lockhart, Katherine B Howell, Christopher A Reid.
Slc35a2 mosaic knockout impacts cortical development, dendritic arborisation, and neuronal firing.
*Awarded the best ‘data blitz’ talk prize by the convenors of the Meeting and visiting Professor Fernando Cendes.

Translational Neurogenetics Mini-Retreat 2024 – Oral Presentation.
MOGHE Model: Functional Confirmation that Low Frequency Variants are Significant.

Epilepsy Research Retreat 2023 – Oral Presentation and Chapter.
James Spyrou, Hannah Vanyai, Snezana Maljevic, Paul Lockhart, Katherine Howell, Christopher Reid.
Mechanistic insights gained from a novel mouse model of MOGHE.

International Congress of Genetics (ICG) 2023 – Poster Presentation.
James Spyrou, Hannah Vanyai, Snezana Maljevic, Paul Lockhart, Katherine Howell, Christopher Reid.
Recapitulation of a heterotopic neuron phenotype in a novel mouse model of MOGHE using in utero electroporation and CRISPR/Cas9.
*Received a travel award for the abstract by the convenors of the Congress.

Epilepsy Melbourne Meeting 2023 – Oral and Poster Presentation.
James Spyrou, Hannah Vanyai, Snezana Maljevic, Paul Lockhart, Katherine Howell, Christopher Reid.
Recapitulation of a heterotopic neuron phenotype in a novel mouse model of MOGHE using in utero electroporation and CRISPR/Cas9.

Translational Neurogenetics Mini-Retreat 2023 – Oral Presentation.
Recapitulation of a heterotopic neuron phenotype in a novel mouse model of MOGHE.

Australian Neuroscience Society (ANS) Annual Meeting 2022 – Poster Presentation.
James Spyrou, Paulo Pinares-Garcia, Chaseley McKenzie, Ian Forster, Ming Shiuan Soh, Erlina Mohamed Syazwan, Mohammed Atif, Christopher Reid.
Antidepressant-like activity of a brain penetrant HCN channel blocker in mice.

Epilepsy Melbourne Meeting 2022 – Poster Presentation.
James Spyrou, Paulo Pinares-Garcia, Chaseley McKenzie, Hannah Vanyai, Michael Hildebrand, Christopher Reid.
Characterisation of a Mouse Model of Tuberous Sclerosis Complex (TSC) and Focal Cortical Dysplasia Type 2B (FCD2B) using In Utero Electroporation.
*Awarded the best poster prize by representatives of the Australian Epilepsy Project.

International Society for Stem Cell Research (ISSCR) Annual Meeting 2018 – Poster Presentation.
James Spyrou, David K Gardner, Alexandra J Harvey.
Transcriptomic and metabolic analyses reveal reprogramming conditions impact the human iPSC response to oxygen and identify retention of somatic cell metabolic memory.
*Received a travel award supported by the ASSCR and the NSCFA for the abstract.

Stem Cells Australia (SCA) Retreat 2017 – Poster Presentation.
James Spyrou, David K Gardner, Alexandra J Harvey.
Long-term mitochondrial alterations in hiPSC can be induced by reprogramming at physiological oxygen.

©2025– James Spyrou
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