Selected Publications

Spyrou J., Escobar I., Bordey A., Reid C. A. (2025). Aberrant HCN4 Channel Expression: Impacts on Neuronal Excitability and Implications for Epilepsy Pathogenesis. British Journal of Pharmacology, 182(23):5693-5705. DOI: 10.1111/bph.70218. PMID: 41084323

Bleakley L. E., McKenzie C. E., Aung K. P., Soh M. S., Spyrou J., Forster I. C., Reid C. A. (2025). Org 34167 rescues voltage dependence of mutant channels and normalises hyperexcitability in HCN1 epilepsy. Epilepsia, 66(12): 5082-5095. DOI: 10.1111/epi.18585. PMID: 40762985

Spyrou J., Aung K. P., Vanyai H., Leventer R. J., Maljevic S., Lockhart P. J., Howell K. B., Reid C. A. (2024). Slc35a2 mosaic knockout impacts cortical development, dendritic arborisation, and neuronal firing. Neurobiology of Disease, 201:106657. DOI: 10.1016/j.nbd.2024.106657. PMID: 39236911

Pinares-Garcia P.*, Spyrou J.*, McKenzie C. E., Forster I. C., Soh, M. S., Syazwan E. M., Atif M., Reid C. A. (2023). Antidepressant-like activity of a brain penetrant HCN channel blocker in mice. Frontiers in Pharmacology, 14:1159527. *These authors contributed equally. DOI: 10.3389/fphar.2023.1159527. PMID: 37234718

Spyrou J., Gardner D. K., Harvey A. J. (2019). Metabolomic and transcriptional analyses reveal atmospheric oxygen during human induced pluripotent stem cell generation impairs metabolic reprogramming. Stem Cells, 37(8):1042-1056. DOI: 10.1002/stem.3029. PMID: 31042329

Spyrou J., Gardner D. K., Harvey A. J. (2019). Metabolism is a key regulator of induced pluripotent stem cell reprogramming. Stem Cells International, 2019:7360121. DOI: 10.1155/2019/7360121. PMID: 31191682

©2025– James Spyrou
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